Empowering Innovation with AI-Driven protein Engineering services
AI-Powered Protein Engineering Services
Engineering proteins with improved stability, activity, binding affinity, manufacturability, and developability requires balancing multiple molecular properties simultaneously. Traditional protein engineering often relies on generating and screening thousands of variants, making optimization both time-consuming and resource-intensive.
Neoncorte Bio provides AI-driven protein engineering services that combine computational biology, machine learning, structural biology, and modern protein engineering to accelerate protein optimization while reducing experimental burden.
Our computational workflows help biotechnology companies, pharmaceutical organizations, diagnostics developers, industrial manufacturers, and synthetic biology teams identify high-potential protein variants before laboratory validation.
Our Protein Engineering Services
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Computational Protein DesignIdentify rational engineering opportunities using protein sequence analysis, structural information, and AI-guided prediction. -
AI-Guided Mutation PrioritizationRank amino acid substitutions based on their predicted effects on target protein properties before laboratory experiments. -
Computational MutagenesisEvaluate single mutations and mutation combinations computationally to guide focused engineering strategies. -
Virtual Deep Mutational Scanning (DMS)Explore millions of possible protein variants computationally to prioritize the most promising candidates. -
Machine Learning-Guided Directed EvolutionCombine predictive AI models with iterative laboratory validation to reduce screening effort and accelerate optimization. -
Smart Library DesignDevelop focused mutation libraries that maximize useful sequence diversity while minimizing experimental workload. -
Multi-Parameter Protein OptimizationSimultaneously optimize stability, activity, affinity, expression, manufacturability, aggregation resistance, and additional engineering objectives. -
Design-Build-Test-Learn (DBTL) SupportIntegrate computational prediction with experimental data to continuously improve predictive performance during iterative protein engineering.
Protein Engineering Objectives
Our services support optimization of:
- Protein stability
- Thermostability
- Melting temperature (Tm)
- Catalytic activity
- Catalytic efficiency
- Binding affinity
- Protein developability
- Manufacturability
- Expression yield
- Aggregation resistance
- Protein solubility
- pH stability
- Solvent tolerance
- Oxidative stability
- Freeze-thaw stability
- Cofactor specificity
- Substrate specificity
- Enantioselectivity
- Antibody viscosity
- Multi-objective optimization
AI Technologies Behind Our Services
Neoncorte Bio integrates multiple computational technologies to accelerate protein engineering:
- Protein language models (PLMs)
- Computational protein engineering
- Structural biology
- Zero-shot mutation prediction
- Computational mutagenesis
- Virtual Deep Mutational Scanning
- Protein fitness landscape prediction
- Epistasis prediction
- Higher-order mutation prediction
- Active learning
- Bayesian optimization
- Multi-objective optimization
Protein Classes We Support
Our protein engineering services are applicable to:
- Industrial enzymes
- Therapeutic proteins
- Monoclonal antibodies
- Antibody fragments
- Diagnostic proteins
- Biosensor proteins
- Cytokines
- Growth factors
- Binding proteins
- Receptor proteins
- Synthetic biology proteins
- Engineered enzymes
- Novel protein scaffolds
- Fusion proteinstives.
Industries We Serve
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Biopharmaceutical Development
Optimize therapeutic proteins, antibodies, biologics, and protein drug candidates. -
Industrial Biotechnology
Engineer proteins and enzymes for sustainable manufacturing and industrial biocatalysis. -
Diagnostics
Improve proteins used in molecular diagnostics, biosensors, and analytical platforms. -
Synthetic Biology
Optimize proteins for engineered metabolic pathways and synthetic biological systems. -
Food & Beverage
Develop proteins and enzymes for food processing, fermentation, ingredient manufacturing, and specialty applications.
Design-Build-Test-Learn (DBTL) Collaboration
Our protein engineering services integrate computational prediction with laboratory experimentation through an iterative DBTL framework.
Design
Analyze protein sequences, structures, and engineering objectives.
Build
Prioritize mutations and focused libraries for experimental evaluation.
Test
Incorporate laboratory results into predictive models.
Learn
Continuously improve predictive models using newly generated laboratory data.
Each cycle improves engineering efficiency while reducing unnecessary experimental screening.
Analyze protein sequences, structures, and engineering objectives.
Build
Prioritize mutations and focused libraries for experimental evaluation.
Test
Incorporate laboratory results into predictive models.
Learn
Continuously improve predictive models using newly generated laboratory data.
Each cycle improves engineering efficiency while reducing unnecessary experimental screening.
Why Choose Neoncorte Bio?
Our protein engineering services combine expertise in:
- Artificial intelligence
- Machine learning
- Protein engineering
- Computational biology
- Protein language models
- Structural biology
- Computational mutagenesis
- Deep Mutational Scanning (DMS)
- Protein fitness landscape prediction
- Active learning
- Bayesian optimization
- Multi-parameter optimization
- Design-Build-Test-Learn (DBTL)
Who We Work With
We collaborate with:
- Biotechnology companies
- Pharmaceutical companies
- Industrial biotechnology companies
- Antibody developers
- Diagnostic companies
- Synthetic biology startups
- CROs and CDMOs
- Academic research institutions
Frequently Asked Questions (FAQs)
Our platform harnesses advanced artificial intelligence and machine learning to design, optimize, and engineer proteins tailored to your specific requirements. Whether you need improved enzyme efficiency, novel protein functions, or tailored biotherapeutics, our solutions streamline the protein design process and reduce time-to-market.
Our services are ideal for biotechnology and pharmaceutical companies, academic research labs, industrial manufacturers, and any organization involved in protein-based product development. Applications include enzyme optimization, biocatalyst development, therapeutic protein design, and more.
The process begins with your input data, such as protein sequences, structural information, and desired functional attributes. Our AI algorithms then generate a library of potential protein variants and use predictive modeling to evaluate their stability, activity, and specificity. The top candidates are ranked and provided for further experimental validation, thereby reducing the number of required lab iterations.
Our platform is versatile and can be applied to a wide range of proteins, including enzymes, structural proteins, and therapeutic proteins. We can optimize existing proteins or design novel ones for applications in catalysis, biopharmaceuticals, diagnostics, and more.
Absolutely. We work closely with you to tailor our AI models and algorithms to your target proteins and desired outcomes. This includes integrating proprietary data and fine-tuning parameters to ensure that our platform delivers the most relevant and high-performing protein candidates for your application.
Our platform offers robust API support and standard data export formats (e.g., CSV, JSON) to seamlessly integrate with your Laboratory Information Management Systems (LIMS) and other data analytics pipelines. We also provide comprehensive onboarding and training to ensure a smooth adoption process.
Our models are trained on extensive datasets of protein interactions, structural data, and experimental results. We continuously refine our algorithms with real-world feedback to improve prediction accuracy. While our computational predictions are highly reliable, we recommend subsequent in vitro or in vivo validation to confirm the performance of the engineered proteins.
Yes, we provide collaborative support throughout the validation process. Our team can help design proof-of-concept studies and coordinate with your wet lab partners to verify the performance of our predicted protein variants.
We offer flexible pricing models based on the scope and duration of your project. Options include subscription-based plans for ongoing R&D, as well as project-specific pricing for one-off protein engineering campaigns. Please contact us for a personalized consultation and detailed quote.
Our dedicated customer support team is available to assist you at every stage—from initial onboarding and technical training to troubleshooting and ongoing optimization. We offer support via email, phone, and live chat, along with detailed documentation and a comprehensive FAQ section.
Accelerate Your Protein Engineering Program
Contact Neoncorte Bio to discuss your protein engineering project and discover how AI-assisted computational engineering can accelerate your development program
Neoncorte Bio
Where AI Meets Biotechnology
Neoncorte Bio is at the forefront of the convergence between artificial intelligence and protein engineering. Our team comprises experts in computational biology, bioinformatics, and machine learning, all driven by a mission to accelerate innovation in protein design. By leveraging our advanced AI models, we provide unparalleled solutions that enhance efficiency, reduce costs, and push the boundaries of what's possible in protein engineering
US, UK, Germany, Israel, Slovenia
Global Partner Network
Our network connects Neoncorte Bio's AI-driven protein engineering capabilities with wet-lab validation, bioprocess development and industrial biotechnology expertise.
Wet-Lab CROs, CDMOs/Bioprocess, Enzyme Manufacturers, Biotech & Research
Wet-Lab CROs, CDMOs/Bioprocess, Enzyme Manufacturers, Biotech & Research
Proud Member of Leading Global AI Programs
Neoncorte Bio is part of the NVIDIA Inception and Nebius for Startups programs — two of the world’s leading ecosystems for high-performance AI innovation. These partnerships strengthen our ability to deliver next-generation AI-driven protein, enzyme, and aptamer engineering.
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As a member of NVIDIA Inception, Neoncorte Bio gains access to cutting-edge GPU technologies, expert guidance, and a global AI ecosystem that supports companies from prototype to production. The program empowers us to explore new AI opportunities and build high-performance biological design pipelines powered by NVIDIA’s world-class platform. -
Through Nebius for Startups, we gain access to high-performance compute infrastructure optimized for large-scale AI workloads, along with hands-on technical guidance and a strong community of innovative AI companies. Nebius enables us to train and deploy complex biological models more efficiently — accelerating enzyme, protein, and aptamer design while supporting rapid scaling of our R&D pipelines.
Publications
Scientific Publication of Neoncorte Bio Team
- Modification of natural enzymes to introduce new properties and enhance existing ones is a central challenge in bioengineering. This study is focused on the development of Taq polymerase mutants that show enhanced reverse transcriptase (RTase) activity while retaining other desirable properties such as fidelity, 5′-3′ exonuclease activity, effective deoxyuracil incorporation, and tolerance to locked nucleic acid (LNA)-containing substrates.
- The transcriptomic data are being frequently used in the research of biomarker genes of different diseases and biological states. The most common tasks there are the data harmonization and treatment outcome prediction. Both of them can be addressed via the style transfer approach. Either technical factors or any biological details about the samples which we would like to control (gender, biological state, treatment, etc.) can be used as style components.
- List of all Neoncorte Bio publications dedicated to Molecular Biology, Biotechnology, Artificial Intelligence and Artificial Neural Networks, published mostly by Nikolay Russkikh, CEO of Neoncorte Bio
Our Expertise in Action
With extensive experience in AI applications and software engineering tailored to the life sciences, we specialize in solving complex challenges and delivering innovative solutions for our customers. Our work demonstrates a deep understanding of cutting-edge technologies and their application in the real world.
Here are examples of the types of projects we have successfully delivered:
Here are examples of the types of projects we have successfully delivered:
- Automated NGS Data Analysis:Designed a production-grade solution for the automated processing, annotation, and analysis of Next-Generation Sequencing (NGS) data.
- Single-Cell Data Integration:Built state-of-the-art tools for integrating multimodal single-cell data, achieving recognition for technical excellence.
- Metagenomic Classification Algorithms:Developed advanced methods for classifying sequencing reads in metagenomics research.
- High-Throughput Image Processing Pipelines:Engineered an efficient pipeline to process millions of sequencing images with exceptional accuracy.
- Cell Counting via AI:Created a computer vision solution for precise cell counting in microphotography images, streamlining data analysis.
Get in touch with our team
Phone: +1-503-754-3958 USA
Email: contact@neoncorte.com
Email: contact@neoncorte.com
© All Rights Reserved. Neoncorte Bio. 2024-2026
contact@neoncorte.com
contact@neoncorte.com